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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

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Coating bacteria for anti-tumor therapy.

Jiahui Wang1, Ning Guo1, Weiliang Hou1,2

  • 1Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

Frontiers in Bioengineering and Biotechnology
|October 3, 2022
PubMed
Summary

Living bacteria offer unique advantages for anti-tumor therapy due to their targeting and colonization abilities. Coating bacteria with materials enhances therapeutic effects and safety for cancer treatment.

Keywords:
bacteriacoatingmaterialstumor targetingtumor therapy

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Area of Science:

  • Biomedical Engineering
  • Oncology
  • Microbiology

Background:

  • Therapeutic bacteria show promise for anti-tumor therapy, leveraging their natural targeting and colonization in the tumor microenvironment.
  • While successful in mouse models, bacterial anti-tumor therapies face limitations in therapeutic efficacy and biosafety for clinical use.

Purpose of the Study:

  • This review summarizes materials used for coating living bacteria in cancer therapy.
  • It explores strategies to enhance bacteria-mediated anti-tumor effects and improve safety.

Main Methods:

  • Literature review of studies on coating bacteria for cancer therapy.
  • Analysis of material properties and their impact on bacterial function and anti-tumor efficacy.

Main Results:

  • Various materials can be used to coat therapeutic bacteria, improving their performance.
  • Coating strategies aim to enhance tumor targeting, colonization, and therapeutic payload delivery.

Conclusions:

  • Coating living bacteria with advanced materials presents a promising strategy for synergistic cancer therapy.
  • Further research is needed to overcome challenges and translate these approaches to clinical applications.