Microbiome engineering: engineered live biotherapeutic products for treating human disease

Area of Science:

• Microbiology
• Biotechnology
• Medical Science

Background:

• The human microbiota plays a role in numerous diseases, including neurological disorders, cancer, and inflammatory conditions.
• Microbiome engineering aims to modify the host-microbiota system for therapeutic outcomes.
• Engineered microorganisms offer a promising approach for targeted therapeutic functions.

Purpose of the Study:

• To review the progress of clinical studies involving microbiome engineering.
• To focus on the development and application of engineered live biotherapeutic products.
• To highlight the transition of microbiome engineering concepts from laboratory models to clinical trials.

Main Methods:

• Review of current clinical trials and research in microbiome engineering.
• Focus on engineered live biotherapeutic products (LBPs).
• Assessment of the translational progress of microbiome engineering strategies.

Main Results:

• Microbiome engineering has advanced significantly, moving towards clinical applications.
• An increasing number of clinical trials are evaluating the safety and efficacy of these engineered treatments.
• Engineered live biotherapeutic products represent a key area of development.

Conclusions:

• Microbiome engineering, particularly with engineered LBPs, shows significant therapeutic potential.
• Clinical trials are crucial for validating the safety and efficacy of these novel treatments.
• The field is rapidly evolving, with promising advancements in human health applications.