COVID-19 and the cardiovascular system-current knowledge and future perspectives.

Area of Science:

• Cardiology
• Infectious Diseases
• Virology

Background:

• The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in high mortality rates globally.
• SARS-CoV-2 affects multiple physiological systems, with increasing evidence pointing to cardiovascular system involvement.
• The precise mechanisms linking SARS-CoV-2 infection to cardiovascular complications remain unclear.

Purpose of the Study:

• To review current knowledge on SARS-CoV-2's impact on the cardiovascular system.
• To highlight the pathophysiological mechanisms underlying COVID-19-related cardiovascular complications.
• To identify future research directions in this critical area.

Main Methods:

• This mini-review synthesizes existing literature and research findings.
• It focuses on the interaction between SARS-CoV-2 and the cardiovascular system.
• The review discusses emerging evidence and expert perspectives.

Main Results:

• SARS-CoV-2 infection is associated with a wide range of cardiovascular complications.
• Potential mechanisms include direct viral invasion, inflammatory responses, and endothelial dysfunction.
• Understanding these pathways is crucial for managing COVID-19 patients.

Conclusions:

• The cardiovascular system is a significant target of SARS-CoV-2, contributing to severe disease and mortality.
• Further investigation into the intricate pathophysiological mechanisms is essential.
• This knowledge will guide the development of targeted therapies and improved patient care strategies.