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Updated: Aug 27, 2025

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Management of the secondary growth defect
Nadeem R Saeed1,2, Barbara Gerber2
1Department of Oral and Maxillofacial Surgery, Great Ormond Street Hospital, London, WC1N 3JH, United Kingdom.
Abstract:
Temporomandibular reconstruction has clear aims including the restoration of mandibular form and function, to decrease patient disability and to prevent disease progression. In addition paediatric patients have growth and re-modelling considerations and the need to minimise any secondary growth defect. The involvement of a multidisciplinary team is deemed essential for both the child and parents. In some patients crisis intervention may be required and early reconstruction might be necessary dependant on the severity of impairment. The aetiology of end stage TMJ disease, unilateral/bilateral disease and the degree of patient compromise will guide timing and choice of treatment. Reducing repeated surgery and facilitating patient compliance may potentiate mandibular growth.
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