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Updated: Aug 27, 2025

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Sodium selenite may be not the optimal speciation as an effective therapy for arsenic-induced
Xiao-Hua Ren1, Xiao-Xuan Wang1, Lian-Ping He2
1School of Medicine, Taizhou University, Taizhou 318000, Zhejiang Province, China.
Abstract:
Major depressive disorder is a serious and prevalent neuropsychiatric disorder, affecting more than 350 million people worldwide. Here, sodium selenite (SS) was selected as the selenite supplement to improve the behavior in a mouse model of depression induced by As. SS may be not the optimal speciation for selenite supplementation and the source of the SS used in the study was not disclosed. There are many mouse models of depression and anxiety; however, in the current study, a classical mouse model of depression was not used. Thus, several questions still need to be further discussed. Taken together, the results indicate that SS may be not the optimal speciation as an effective therapy for As-induced anxiety-/depression-like behavior.
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