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Microvessel density in differentiated thyroid carcinoma: A systematic review and meta-analysis
Konstantinos Perivoliotis1, Athina A Samara2, Prodromos Koutoukoglou3
1Department of Surgery, University Hospital of Larissa, Larissa 41110, Greece.
World Journal of Methodology
|October 3, 2022
Summary
Microvessel density (MVD) in differentiated thyroid carcinoma (DTC) impacts patient survival. Lower MVD is linked to better disease-free survival and reduced recurrence rates in DTC patients.
Area of Science:
- Oncology
- Pathology
- Medical Statistics
Background:
- Microvessel density (MVD) is a measure of tumor neovascularization.
- The prognostic significance of MVD in differentiated thyroid carcinoma (DTC) is not well-established.
Purpose of the Study:
- To evaluate the association between tumoral MVD and survival outcomes in patients with DTC.
- To synthesize existing evidence on MVD as a prognostic marker for DTC.
Main Methods:
- A systematic meta-analysis adhering to PRISMA guidelines.
- Literature search conducted across Medline, Web of Science, and Scopus databases.
- Statistical analysis employed fixed-effects or random-effects models based on Cochran's Q test.
Main Results:
- Nine studies were included, analyzing MVD in DTC.
- Lower MVD tumors demonstrated superior 10-year disease-free survival (OR: 0.21).
- Higher MVD was associated with increased recurrence rates and regional lymph node involvement.
Conclusions:
- Tumoral MVD is a significant prognostic factor for differentiated thyroid carcinoma.
- Further high-quality prospective studies are needed to confirm these findings and address study limitations.
