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Updated: Aug 26, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

A simple and reliable microfabrication process for a programmable microvalve array.

Zachary Estlack¹, Beau Compton², Md Enayet Razu²

¹The University of Utah, United States.

|October 3, 2022

Summary

We present a reliable method for creating a programmable microvalve array (PMA) and integrating it with microcapillary electrophoresis chips. This technique enhances chip yield through quality control and selective bonding for complex microfluidic devices.

Keywords:

Capillary electrophoresis integration Microcontact printing Microvalve array fabrication Microvalve design PDMS soft-lithography

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Last Updated: Aug 26, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

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Published on: October 1, 2007

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Published on: January 27, 2017

Area of Science:

Microfluidics
Materials Science
Biotechnology

Background:

Microfluidic devices require precise fabrication for complex functionalities.
Integrating microvalves with analytical chips like capillary electrophoresis is challenging.

Purpose of the Study:

To detail a reliable fabrication methodology for a programmable microvalve array (PMA).
To demonstrate the integration of the PMA with a glass microcapillary electrophoresis chip.
To provide quality assurance steps for maximizing chip yield.

Main Methods:

Fabrication of multilayered polydimethylsiloxane (PDMS) microvalve arrays.
Selective bonding of PDMS to glass using microcontact printing.
Integration of the PMA with microcapillary electrophoresis chips.

Main Results:

A robust and reproducible methodology for PMA fabrication was established.
Successful integration of the PMA with microcapillary electrophoresis chips was achieved.
Quality control procedures were identified to improve fabrication success rates.

Conclusions:

The described methodology offers a reliable approach for fabricating complex microfluidic devices.
This technique is adaptable for various multilayered PDMS devices requiring selective bonding and integration.
Implementation of quality assurance checks is crucial for maximizing chip yield in microfluidic fabrication.