Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dysrhythmias IV: Characteristics of Bradyarrhythmias01:18

Dysrhythmias IV: Characteristics of Bradyarrhythmias

108
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
108
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

19
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
19
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

37
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
37
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

103
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
103
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

188
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
188
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

418
β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation,...
418

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What Is Looked for Is Found: Arrhythmia Detection in ALLEVIATE-HF.

Journal of the American College of Cardiology·2026
Same author

Optimal pace timing for left bundle branch area pacing with or without an additional LV lead: results from the CSPOT study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Frailty and risk of death without device therapy among patients with primary prophylaxis implantable cardioverter-defibrillators: The CERTITUDE Registry.

Heart rhythm·2026
Same author

Early is on time: Minimizing implantable cardioverter-defibrillator shocks through expedited antitachycardia pacing.

Heart rhythm O2·2025
Same author

Approach to Atrial Pacing in an Extracardiac Fontan Patient: Avoiding Trans-Baffle Puncture Through Electroanatomical Mapping.

JACC. Clinical electrophysiology·2025
Same author

Mechanism of Typical Atrial Flutter in a Patient After Cardiac Transplant: Functional Slowing From Geometric Distortion.

JACC. Case reports·2025
Same journal

What role does the Notch signaling pathway play in exercise-related metabolic and neurological adaptations? A molecular-to-systems perspective.

Frontiers in physiology·2026
Same journal

Variation in skin barrier function throughout smoltification in Atlantic salmon (<i>Salmo salar</i>).

Frontiers in physiology·2026
Same journal

Correction: What role does the Notch signaling pathway play in exercise-related metabolic and neurological adaptations? A molecular-to-systems perspective.

Frontiers in physiology·2026
Same journal

Effect of high intensity interval Nordic walking and strength training on selected biomarkers of metabolic syndrome in postmenopausal women with abdominal obesity: a quasi-experimental studies.

Frontiers in physiology·2026
Same journal

The interplay between sexual activity, athletic performance, and recovery in athletes: a narrative review.

Frontiers in physiology·2026
Same journal

The alveolar edema equation.

Frontiers in physiology·2026
See all related articles

Related Experiment Video

Updated: Aug 26, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K

Cardiac resynchronization considerations in left bundle branch block.

Nathan W Kong1, Gaurav A Upadhyay2

  • 1Department of Internal Medicine, University of Chicago Medicine, Chicago, IL, United States.

Frontiers in Physiology
|October 3, 2022
PubMed
Summary
This summary is machine-generated.

Cardiac resynchronization therapy (CRT) using biventricular pacing effectively treats heart failure but has non-responders. Conduction system pacing (CSP) offers an alternative, with hybrid approaches showing promise for improved outcomes.

Keywords:
biventricular pacingcardiac resynchronization therapyconduction system pacingleft bundle branch area pacingleft bundle branch block

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

864
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.8K

Related Experiment Videos

Last Updated: Aug 26, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

864
Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction
06:57

Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

Published on: January 31, 2019

14.8K

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) with biventricular pacing (BiVP) is standard for heart failure with wide QRS.
  • Seminal trials focused on left bundle branch block (LBBB) patterns, assuming a direct correlation with conduction block.

Purpose of the Study:

  • To explore the heterogeneity of LBBB pathophysiology and its implications for CRT response.
  • To introduce conduction system pacing (CSP) and hybrid approaches as alternatives for CRT non-responders.

Main Methods:

  • Review of existing clinical data and trial outcomes for BiVP-CRT.
  • Discussion of emerging evidence for Conduction System Pacing (CSP) and combined CRT-CSP strategies.
  • Emphasis on physiologic phenotyping of LBBB patterns.

Main Results:

  • LBBB patterns encompass diverse underlying pathologies, not solely complete conduction block.
  • A significant number of patients do not respond to traditional BiVP-CRT.
  • CSP and hybrid pacing show potential for improving CRT efficacy in select patient groups.

Conclusions:

  • Understanding the varied pathophysiology of LBBB is crucial for optimizing CRT.
  • Conduction system pacing and hybrid techniques represent promising advancements in CRT for non-responders.
  • Further research into physiologic phenotyping will refine patient selection for different CRT approaches.