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Updated: Aug 26, 2025

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
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Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice

Published on: February 9, 2014

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Autophagy in severe acute respiratory syndrome coronavirus 2 infection

Di Chen1, Hong Zhang1,2

  • 1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Current Opinion in Physiology
|October 3, 2022
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks the autophagy pathway, a cellular defense mechanism, to enhance its replication and spread. Understanding this interaction may lead to new COVID-19 treatments targeting autophagy.

Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection involves host cell endomembrane remodeling.
  • Autophagy, a cellular degradation process, plays a dual role in antiviral defense and viral manipulation.
  • SARS-CoV-2 interacts with autophagy, impacting viral replication and host immune responses.

Purpose of the Study:

  • To review the intricate relationship between SARS-CoV-2 and autophagy.
  • To elucidate how viral proteins modulate autophagy for replication and transmission.
  • To discuss the pathological consequences of autophagy dysregulation and potential therapeutic strategies.

Main Methods:

  • Literature review focusing on the interplay between SARS-CoV-2 and autophagy.
  • Analysis of mechanisms by which SARS-CoV-2 evades or exploits autophagy.
  • Examination of research on pharmacological interventions targeting autophagy for COVID-19.

Main Results:

  • SARS-CoV-2 proteins actively manipulate the autophagy pathway to facilitate viral replication and spread.
  • Dysregulation of autophagy by SARS-CoV-2 contributes to disease pathogenesis.
  • Autophagy modulation presents a potential therapeutic avenue for COVID-19 treatment.

Conclusions:

  • The interaction between SARS-CoV-2 and autophagy is critical for viral propagation and pathogenesis.
  • Targeting autophagy pathways offers promising therapeutic strategies for managing COVID-19.
  • Further research into SARS-CoV-2-autophagy interplay is essential for developing effective treatments.

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