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Left ventricular function in malnutrition.

P B Alden, R D Madoff, T J Stahl

    The American Journal of Physiology
    |August 1, 1987
    PubMed
    Summary

    Acute protein-calorie malnutrition causes cardiac atrophy in dogs, leading to reduced cardiac output and contractility. Myocardial function remains intact, indicating atrophy is due to muscle mass loss, not intrinsic changes.

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    Area of Science:

    • Cardiology
    • Nutritional Science
    • Physiology

    Background:

    • Protein-calorie malnutrition is a global health concern.
    • Cardiac function can be significantly impacted by nutritional status.
    • Understanding the cardiac effects of malnutrition is crucial for patient management.

    Purpose of the Study:

    • To investigate the impact of acute protein-calorie malnutrition on cardiac function in a canine model.
    • To differentiate between cardiac atrophy and intrinsic myocardial dysfunction.

    Main Methods:

    • Twenty-one dogs were divided into a control group (regular diet) and a malnutrition group (protein-calorie deficient diet) for 3 weeks.
    • Cardiac function was assessed using ultrasonic left ventricular dimension transducers and micromanometers in awake, intact animals.
    • Measurements included heart rate, ejection fraction, cardiac output, cardiac index, and contractility indices (EmaxPV).

    Main Results:

    • Malnourished dogs exhibited significant cardiac atrophy, with reduced cardiac mass and wall thinning.
    • Heart rate decreased, while ejection fraction increased in the malnourished group.
    • Cardiac output fell, but cardiac index remained unchanged; global ventricular contractility (EmaxPV) showed a slight, non-significant decrease.
    • Intrinsic myocardial properties and response to beta-adrenergic stimulation were unaffected.

    Conclusions:

    • Acute protein-calorie malnutrition leads to cardiac atrophy in dogs, characterized by decreased cardiac output and contractility.
    • The observed changes are primarily due to loss of cardiac muscle mass, not intrinsic myocardial dysfunction.
    • Nutritional interventions are essential to prevent or reverse cardiac complications associated with malnutrition.

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