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Related Concept Videos

Stereoisomerism02:52

Stereoisomerism

12.3K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.3K
Prochirality02:05

Prochirality

3.9K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.9K
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

5.9K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.9K
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

12.0K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
12.0K
Naming Enantiomers02:21

Naming Enantiomers

20.9K
The naming of enantiomers employs the Cahn–Ingold–Prelog rules that involve assigning priorities to different substituent groups at a chiral center. Each enantiomer, being a distinct molecule, is assigned a unique name by the Cahn–Ingold–Prelog (CIP) rules, also called the R–S system. The prefix R- or S- attached to the chiral centers in an enantiomer is dependent on the spatial arrangement of the four substituents on the chiral center. The R–S system...
20.9K
Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

9.1K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
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Updated: Aug 26, 2025

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
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Atomically Precise Enantiopure Bimetallic Janus Clusters.

Yao Li1, Qiu-Xu Zang1, Xi-Yan Dong1,2

  • 1Henan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostical Cluster Materials, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

ACS Central Science
|October 3, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed atomically precise bimetallic Janus nanoclusters using gold and transition metals. These novel nanoclusters exhibit unique electronic and chiroptical properties, paving the way for new nanomaterial applications.

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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
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Area of Science:

  • Nanomaterials Science
  • Atomic Physics
  • Surface Chemistry

Background:

  • Asymmetric bimetallic Janus nanocrystals offer unique properties but face challenges in understanding formation and achieving enantiopure synthesis.
  • Atomically precise Janus bimetal nanoclusters are crucial for resolving fundamental issues but have not been realized.

Purpose of the Study:

  • To prepare and structurally resolve atomically precise Janus bimetal nanoclusters.
  • To investigate their interfacial linkage, electronic properties, and self-assembly behavior.

Main Methods:

  • Synthesis of Janus nanoclusters using gold and transition metals (Cu/Cd) with an S/P biligand strategy.
  • Atomic-level structural resolution and characterization of electronic and chiroptical properties.

Main Results:

  • Four Janus nanoclusters (Au/Cu and Au/Cd) were successfully prepared and structurally resolved.
  • Atomic-level interfacial linkage, superatomic orbital splitting, and molecule-like electronic transitions were observed.
  • High dipole moments (up to 45 D) drove 1D nanowire formation via self-assembly.

Conclusions:

  • This study provides fundamental insights into intermetallic nanomaterials.
  • It establishes an avenue for the synthesis of novel Janus nanoclusters with tunable properties.