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Effect and benefit of percutaneous coronary intervention in chronic total occlusion on ventricular repolarization: QT

Ameen Abdulhasan Al Alwany1

  • 1College of Medicine, University of Baghdad, Baghdad, Iraq.

Journal of Medicine and Life
|October 3, 2022
PubMed

Insights

Percutaneous coronary intervention (PCI) significantly reduces corrected QT (QTc) dispersion in patients with chronic total coronary artery occlusion. This finding highlights PCI

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Imaging

Background:

  • ST segment, T wave, and QT interval changes are key electrocardiogram (ECG) parameters for diagnosing ischemic heart disease.
  • Elevated QT dispersion, particularly corrected QT (QTc) dispersion, is linked to myocardial ischemia and coronary artery disease (CAD).
  • Chronic total occlusion (CTO) presents a significant challenge in managing coronary artery disease.

Purpose of the Study:

  • To evaluate changes in surface electrocardiography (ECG) parameters, specifically QTc dispersion, following percutaneous coronary intervention (PCI).
  • To assess the impact of PCI on depolarization and repolarization variations in patients with CTO.
  • To determine if PCI revascularization influences QTc dispersion in CTO patients.

Main Methods:

  • A study involving 110 patients with CTO who underwent PCI revascularization at the Iraqi Center for Heart Disease (October 2020 - February 2021).
  • Twelve-lead ECGs were recorded 12 hours before PCI and over one hour after the intervention.
  • Measured parameters included corrected QT (QTc) interval durations and QTc dispersion, comparing pre- and post-PCI values.

Main Results:

  • A statistically significant change was observed in average QTc interval and QTc dispersion before and after PCI.
  • PCI revascularization in patients with CTO resulted in a major reduction in QTc dispersion.
  • The study demonstrated a significant improvement in ECG repolarization parameters post-intervention.

Conclusions:

  • Percutaneous coronary intervention is effective in reducing QTc dispersion in patients suffering from chronic total coronary artery occlusion.
  • The reduction in QTc dispersion post-PCI suggests an improvement in myocardial electrical stability.
  • ECG parameters like QTc dispersion can serve as valuable indicators of treatment efficacy in CTO patients undergoing PCI.

Keywords:
QT intervalQTc dispersionchronic total occlusion

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