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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Utility of cardiac bioenzymes in predicting cardiovascular outcomes in SARS-CoV-2

Anjani Muthyala1, Sandeep Sasidharan1, Kevin John John2

  • 1Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States.

World Journal of Virology
|October 3, 2022
PubMed

Insights

Cardiac biomarkers like troponin and natriuretic peptides are elevated in COVID-19 patients, indicating cardiovascular injury and predicting poor outcomes. Monitoring these cardiac bioenzymes aids in assessing disease severity and mortality risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Cardiovascular complications are increasingly noted in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
  • Elevated cardiac biomarkers signify ongoing myocardial injury in coronavirus disease 2019 (COVID-19).
  • These biomarkers serve as crucial indicators for assessing disease severity.

Purpose of the Study:

  • To review the variability and clinical utility of cardiac biomarkers in COVID-19.
  • To determine the role of cardiac biomarkers in the diagnosis, prognosis, and clinical outcomes of COVID-19.
  • To evaluate both traditional and novel cardiac bioenzymes.

Main Methods:

  • Comprehensive literature search conducted across PubMed, Medline, and Reference Citation Analysis (RCA).
  • Utilized search terms including "COVID-19" and "cardiac bioenzymes" or "cardiac biomarkers".
  • Employed the latest reference citation analysis tools to identify relevant studies.

Main Results:

  • Elevated cardiac troponin levels in COVID-19 patients correlate strongly with adverse prognosis and myocarditis.
  • Natriuretic peptides (BNP, pro-BNP) are elevated in COVID-19 cardiac injury, regardless of prior heart failure, and predict worse outcomes.
  • Novel biomarkers (presepsin, soluble ST2, copeptin) also indicate cardiovascular injury and poor prognosis in COVID-19.

Conclusions:

  • Admission assessment and serial monitoring of cardiac bioenzymes can predict disease severity and mortality in SARS-CoV-2 infected patients.
  • Cardiac bioenzyme assessment is vital for managing COVID-19 patients with cardiovascular involvement.
  • Further research is essential to fully understand the significance of novel cardiac biomarkers in COVID-19.
Abstract

Keywords:
Brain natriuretic peptideHeart failureOutcomesPrognosisSARS-CoV-2Troponin

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