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Updated: Aug 26, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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Can genetics guide exercise prescriptions in osteoarthritis?

Osvaldo Espin-Garcia1,2, Madhu Baghel3, Navraj Brar4

  • 1Department of Biostatistics, Princess Margaret Cancer Centre and Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada.

Frontiers in Rehabilitation Sciences
|October 3, 2022
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Summary

Genetics may guide exercise prescriptions for osteoarthritis (OA) patients. Understanding genetic and epigenetic factors can personalize exercise benefits for better OA management and care.

Keywords:
disease managementepigeneticsgenomicsinterventionphysical activityprecision medicine

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Area of Science:

  • Orthopedics
  • Genetics
  • Exercise Science

Background:

  • Osteoarthritis (OA) is a prevalent, multifactorial joint disease.
  • Current OA management aims to reduce pain and functional decline using diverse interventions.
  • Identifying optimal interventions for individual OA patients remains challenging.

Purpose of the Study:

  • To explore the potential role of genetics in tailoring exercise prescriptions for OA.
  • To highlight the limited research at the intersection of exercise, genetics, and OA.
  • To identify knowledge gaps and propose future research directions.

Main Methods:

  • Review of key publications on exercise and OA, genetics and OA, and exercise and genetics.
  • Perspective on the integration of genetic and epigenetic factors in OA exercise interventions.

Main Results:

  • Emerging evidence suggests genetics and epigenetics can explain exercise benefits in OA.
  • Epigenetics is identified as a key mechanism mediating exercise's impact on OA outcomes.
  • A significant knowledge gap exists regarding the interplay of exercise, genetics, and OA.

Conclusions:

  • Genetic and epigenetic factors are crucial for understanding personalized exercise responses in OA.
  • Future research should focus on elucidating these mechanisms to optimize OA patient care.
  • Integrating genetic insights into exercise prescriptions holds promise for improved OA management.