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Related Concept Videos

Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Aug 26, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Wearable Surface-Lighting Micro-Light-Emitting Diode Patch for Melanogenesis Inhibition.

Jae Hee Lee1, Yuri Ahn2, Han Eol Lee1,3

  • 1Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Advanced Healthcare Materials
|October 3, 2022
PubMed
Summary

A novel wearable surface-lighting micro-light-emitting diode (SµLED) device offers improved skin care by providing uniform light for treating hyperpigmentation. This SµLED technology demonstrates significant anti-melanogenic effects, outperforming conventional LED devices.

Keywords:
SµLED patchflexible µLEDmelanogenesis Inhibtionphotobiomodulationsurface-lightingwearable optoelectronics

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
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Quantification of Hypopigmentation Activity In Vitro
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Quantification of Hypopigmentation Activity In Vitro

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Materials Science

Background:

  • Wearable light-emitting diode (LED) devices are explored for cosmetic skin treatments like wrinkles, acne, and hyperpigmentation.
  • Current LED stimulators face challenges including inefficient light transfer, heat generation, and uneven irradiation, limiting their therapeutic efficacy and safety.

Purpose of the Study:

  • To develop and evaluate a wearable surface-lighting micro-LED (SµLED) photostimulator for enhanced skin care and cosmetic applications.
  • To address the limitations of conventional LED devices by improving light uniformity, flexibility, and thermal stability.

Main Methods:

  • Fabrication of SµLEDs using a light diffusion layer (LDL), thin film micro-LEDs, and polydimethylsiloxane (PDMS) for uniform 2 × 2 cm² surface lighting.
  • Evaluation of SµLEDs' anti-melanogenic effects through in vitro studies on human skin equivalents (HSEs) and in vivo studies on mouse dorsal skin.

Main Results:

  • The SµLED device achieved uniform surface lighting with 100% emission yields, demonstrating enhanced photostimulation effectiveness.
  • In vitro and in vivo experiments confirmed significant inhibition of melanogenesis by SµLEDs.
  • Reduced levels of melanin, melan-A, tyrosinase, and microphthalmia-associated transcription factor (MITF) were observed with SµLED treatment compared to conventional LED (CLED) devices.

Conclusions:

  • The developed SµLED photostimulator offers a promising solution for effective and safe skin care applications, particularly for hyperpigmentation treatment.
  • SµLED technology provides superior uniform irradiation, flexibility, and thermal stability compared to conventional LEDs.
  • The study validates the anti-melanogenic efficacy of SµLEDs, highlighting their potential in cosmetic dermatology.