Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatic Portal System01:21

Hepatic Portal System

1.8K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.8K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

890
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
890
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

195
The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
195
Liver Physiology01:30

Liver Physiology

913
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
913
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

96
In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
96
Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance01:09

Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance

189
Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance.
Most drugs undergo restrictive clearance, which is proportional to the...
189

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Linear and segmental verrucous epidermal naevus with ipsilateral breast hypoplasia.

Indian journal of dermatology, venereology and leprology·2026
Same author

IGFBP3 repression driven by inflammation links air pollution to placental and developmental defects.

EMBO molecular medicine·2026
Same author

Coexistence of Hemoglobin D and Thalassemia Trait: A Rare Phenomenon with Cardiac Presentation.

The journal of Tehran Heart Center·2025
Same author

Jigsaw as a Revision Module for Enhancing Learning in Biochemistry Among First-Year Medical Students.

Cureus·2024
Same author

Gestational diabetes mellitus (GDM): diagnosis using biochemical parameters and anthropometric measurements during the first trimester in the Indian population.

Hormone molecular biology and clinical investigation·2024
Same author

Perception, acceptance, and adverse effects of COVID-19 vaccines: Insights from Indian population.

Journal of family medicine and primary care·2024

Related Experiment Video

Updated: Aug 26, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.8K

COVID-19: a viewpoint from hepatic perspective.

Abhijeet Brizawasi1, Ashok Kumar Ahirwar2, Prabhat3

  • 1All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

Hormone Molecular Biology and Clinical Investigation
|October 3, 2022
PubMed
Summary

Coronaviruses, including COVID-19, are highly infectious respiratory illnesses. While initially severe, COVID-19 outcomes have improved, but liver injury and risks for hypertensive patients warrant further investigation.

Keywords:
ACECOVID-19SARS-CoV-2complicationshepatic

More Related Videos

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.3K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.5K

Related Experiment Videos

Last Updated: Aug 26, 2025

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

9.8K
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
12:24

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

5.3K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.5K

Area of Science:

  • Virology
  • Infectious Diseases
  • Hepatology

Background:

  • Coronaviruses, known since the last century, are named for their crown-like spikes.
  • COVID-19, caused by a novel coronavirus, is highly infectious, differing from SARS and MERS.
  • Initial high case fatality rates for COVID-19 have decreased; many cases are asymptomatic or present with fever, breathlessness, and GI symptoms.

Purpose of the Study:

  • To review the characteristics of COVID-19, including its pathogenesis and impact on specific patient groups.
  • To discuss the implications of COVID-19 on liver function and potential risks for individuals with pre-existing liver conditions or undergoing immunosuppression.
  • To highlight the need for further research into COVID-19-associated liver injuries and treatment side effects.

Main Methods:

  • Review of existing literature on coronaviruses, SARS, MERS, and COVID-19.
  • Analysis of COVID-19 pathogenesis, particularly its interaction with ACE 2 receptors.
  • Examination of clinical observations regarding COVID-19 symptoms, risk factors (hypertension), and liver enzyme derangements.

Main Results:

  • COVID-19 pathogenesis involves ACE 2 receptors, leading to increased cases and mortality among hypertensive individuals, especially those using ACE inhibitors.
  • Deranged liver enzymes are common in COVID-19, though serious liver injury is less documented, potentially linked to the disease or antiviral drugs.
  • Individuals with autoimmune hepatitis, liver cancer, or immunosuppression require extra precautions.

Conclusions:

  • COVID-19 presents a significant public health challenge with varied clinical manifestations and potential impacts on liver health.
  • Hypertensive patients, particularly those on ACE inhibitors, face elevated risks.
  • Further research is crucial to understand and manage COVID-19-related liver injuries and treatment side effects, especially in vulnerable populations.