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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

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Published on: November 21, 2013

Advancements in antimicrobial nanoscale materials and self-assembling systems.

Jack A Doolan^1,2, George T Williams³, Kira L F Hilton¹

¹School of Chemistry and Forensic Science, University of Kent, Canterbury, Kent CT2 7NH, UK. J.R.Hiscock@Kent.ac.uk.

Chemical Society Reviews

|October 3, 2022

Summary

Antimicrobial resistance (AMR) is a major global health threat, causing more deaths than HIV/AIDS. This review explores novel self-assembling and nanoscale systems to combat AMR infections, offering a guide for future therapeutic development.

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Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

Area of Science:

Biomedical Engineering
Materials Science
Infectious Diseases

Background:

Antimicrobial resistance (AMR) is a critical global health crisis, surpassing HIV/AIDS and malaria in mortality.
The COVID-19 pandemic has exacerbated AMR due to increased antibiotic usage, highlighting the urgent need for new treatments.
AMR poses a significant economic threat, with projected costs exceeding $100 trillion by 2050.

Purpose of the Study:

To provide a comprehensive overview of novel therapeutic strategies against antimicrobial resistance.
To focus on self-assembling systems and nanoscale materials as promising solutions for AMR.
To guide the design and development of next-generation antimicrobial systems.

Main Methods:

Review of current research on self-assembling systems for antimicrobial applications.
Analysis of nanoscale materials and their mechanisms against resistant bacteria.
Discussion of advantages, disadvantages, and key examples of emerging antimicrobial technologies.

Main Results:

Identified self-assembling systems and nanoscale materials as key areas for novel antimicrobial development.
Detailed the mechanisms of action for various innovative therapeutic approaches.
Highlighted the interdisciplinary nature of translating these findings into clinical practice.

Conclusions:

Novel self-assembling systems and nanoscale materials offer promising avenues to combat the growing threat of antimicrobial resistance.
Further research and interdisciplinary collaboration are essential to translate these advanced therapeutic strategies into effective clinical treatments.
Addressing the 'silent pandemic' of AMR requires innovative solutions and a strategic approach to drug development.