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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
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Renin: Measurements, Correlates, and Associations With Long-Term Adverse Kidney Outcomes.
Matthew F Blum1, Jingsha Chen2, Aditya Surapaneni3
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
American Journal of Hypertension
|October 3, 2022
Summary
Higher renin levels measured by SomaScan are linked to increased risks of chronic kidney disease (CKD), end-stage kidney disease (ESKD), and mortality. This method shows moderate correlation with plasma renin activity (PRA).
Area of Science:
- Nephrology
- Biomarker Discovery
- Cardiovascular Research
Background:
- The association between renin and adverse kidney outcomes remains unclear.
- Renin measurement methodologies vary, impacting clinical interpretation.
- Understanding renin's role in kidney disease progression is crucial.
Purpose of the Study:
- To assess clinical correlates of different renin measurements.
- To investigate the association between renin and incident chronic kidney disease (CKD).
- To examine the link between renin and end-stage kidney disease (ESKD) and mortality.
Main Methods:
- Prospective cohort analysis of 9,420 Atherosclerosis Risk in Communities study participants (1996-2019).
- Longitudinal associations of SomaScan renin with CKD, ESKD, and death estimated using Cox proportional hazards models.
- Comparison of SomaScan renin with plasma renin activity (PRA) and Olink renin, with covariate analysis.
Main Results:
- Higher SomaScan renin levels correlated with increased risk of incident CKD, ESKD, and mortality.
- SomaScan renin showed moderate correlation with PRA (r=0.61) and high correlation with Olink renin (r=0.94).
- SomaScan renin and PRA shared similar clinical correlates, with notable differences in associations with age and beta-blocker use.
Conclusions:
- SomaScan aptamer-based renin levels are associated with higher risks of CKD, ESKD, and mortality.
- SomaScan renin demonstrated moderate correlation with PRA, with largely similar clinical covariate associations.
- This study highlights the clinical relevance of SomaScan renin measurements in predicting adverse kidney outcomes and mortality.
Keywords:
aptamerblood pressurechronic kidney diseaseend-stage kidney diseasehypertensionkidneymortalityreninMore Related Videos
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