Related Experiment Video
Updated: Aug 26, 2025
07:46
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
25.4K
Obesity Programs Macrophages to Support Cancer Progression
Abhijeet Singh1, Shyamananda Singh Mayengbam1, Himanshi Yaduvanshi1
1Department of Biotechnology, National Centre for Cell Science, Government of India, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, Maharashtra, India.
Cancer Research
|October 3, 2022
Summary
Obesity promotes cancer by altering macrophage function and inflammation. This review explores how obesity impacts macrophage-tumor interactions and their role in cancer therapy response.
Area of Science:
- Oncology
- Immunology
- Metabolic Syndrome
Background:
- Obesity causes dyslipidemia, insulin resistance, and hypertension, increasing cancer risk.
- Macrophages are crucial in adipose tissue homeostasis and cancer progression.
- Obesity-induced inflammation and metabolic changes affect macrophage behavior in cancer.
Approach:
- This review synthesizes current research on obesity's influence on macrophage-tumor cell interactions.
- It examines how obesity-associated metabolic dysregulation impacts macrophage functionality.
- The role of macrophages in anticancer therapy response under obese conditions is analyzed.
Key Points:
- Obesity disrupts adipose tissue macrophage balance, promoting chronic inflammation.
- Adipokines and metabolic alterations in obesity modulate macrophage activity.
- Macrophages play a dual role in cancer initiation, progression, and therapy response.
Conclusions:
- Obesity significantly impacts macrophage polarization and function, contributing to cancer development.
- Understanding these interactions is vital for developing effective cancer therapies in obese patients.
Related Concept Videos
01:24Obesity
585
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
585
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
02:53Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
02:40Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
01:19Psychoneuroimmunology: Diabetes and Cancer
58
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
58