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Supportive care in pediatric acute myeloid leukemia:Expert-based recommendations of the NOPHO-DB-SHIP consortium

Nira Arad-Cohen1, Bernward Zeller2, Jonas Abrahamsson3

  • 1Department of Pediatric Hemato-Oncology, Rambam Health Care Campus, Haifa, Israel.

Expert Review of Anticancer Therapy
|October 3, 2022
PubMed

Insights

Pediatric acute myeloid leukemia (AML) patients face high risks of complications. This review provides crucial recommendations for managing these risks, aiming to improve treatment outcomes for children and adolescents with AML.

Area of Science:

  • Hematology
  • Pediatric Oncology

Background:

  • Pediatric acute myeloid leukemia (AML) is a significant cause of childhood cancer.
  • Patients with AML are susceptible to severe complications including infections, typhlitis, and cardiotoxicity.
  • Current supportive care guidelines for pediatric AML are lacking definitive approaches to manage or prevent these complications.

Approach:

  • The NOPHO-DB-SHIP consortium convened dedicated meetings to discuss supportive care for pediatric AML.
  • This review synthesizes available data and proposes recommendations for managing children and adolescents with AML.
  • The focus includes hyperleukocytosis, tumor lysis syndrome, coagulation issues, bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.

Key Points:

  • Effective supportive care is vital for improving cure rates in pediatric AML.
  • Recommendations cover critical areas such as infection control, managing oncologic emergencies, and mitigating treatment toxicities.
  • Addressing complications like cardiotoxicity and fertility preservation is essential for long-term patient well-being.

Conclusions:

  • Establishing clear supportive care guidelines is paramount for optimizing outcomes in pediatric AML.
  • These recommendations aim to provide a standardized approach to managing complications in this vulnerable population.
  • Implementing evidence-based supportive care strategies will further enhance survival and quality of life for pediatric AML patients.
Abstract

Keywords:
Acute myeloid leukemiacardiotoxicitychildrencoagulationhyperleukocytosisinfectionsupportive caretumor lysis syndrometyphlitis

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