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SARS-CoV-2 Omicron BA.1 Challenge after Ancestral or Delta Infection in Mice

Mariana Baz, Nikita Deshpande, Charlie Mackenzie-Kludas

    Emerging Infectious Diseases
    |October 3, 2022
    PubMed

    Abstract:

    We assessed cross-reactivity to BA.1, BA.2, and BA.5 of neutralizing antibodies elicited by ancestral, Delta, and Omicron BA.1 SARS-CoV-2 infection in mice. Primary infection elicited homologous antibodies with poor cross-reactivity to Omicron strains. This pattern remained after BA.1 challenge, although ancestral- and Delta-infected mice were protected from BA.1 infection.

    Keywords:
    AustraliaCOVID-19K18-hACE2 miceOmicron BA.1SARS-CoV-2SARS-CoV-2 variantsancestralchallengecoronavirus diseasecross-protectionimmunogenicitymiceneutralizing antibodiesrespiratory infectionssevere acute respiratory syndrome coronavirus 2vaccine-preventable diseasesviruseszoonoses

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