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Updated: Aug 26, 2025

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
Published on: February 22, 2018
High-density activation map of atrial tachycardia within left atrial appendage
Yasuharu Matsunaga-Lee1, Yasuyuki Egami1, Masami Nishino1
1Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
Insights
Identifying the critical isthmus in atrial tachycardia (AT) is key for effective catheter ablation (CA). This case highlights successful AT ablation in the left atrial appendage (LAA) using a novel mapping strategy.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Recurrent atrial tachycardia (AT) post-catheter ablation (CA) necessitates precise identification of the critical isthmus.
- Optimal CA requires minimizing myocardial injury while maximizing ablation efficacy.
- Previous CA for atrial fibrillation (AF) and AT included pulmonary vein isolation and linear ablation.
Observation:
- An 81-year-old woman with recurrent AT after prior CA presented with palpitations.
- High-density mapping revealed a figure-of-eight activation pattern in the left atrial appendage (LAA).
- The critical isthmus was located in the mid-LAA with a non-fractionated local electrogram.
Findings:
- A single radiofrequency application at the identified mid-LAA critical isthmus successfully terminated the AT.
- The patient remained free from AT for 28 months post-ablation.
- Unlike typical AT ablation targeting fractionated electrograms, this case utilized a non-fractionated electrogram at the critical isthmus, avoiding potential complications.
Implications:
- 3D electro-anatomical mapping systems enable precise identification of critical isthmuses for AT ablation within the LAA.
- This approach offers a new therapeutic strategy for complex ATs, particularly within the LAA.
- Accurate isthmus identification can refine CA, improving outcomes and patient safety.
Abstract:
Identification of the critical isthmus of the reentrant tachycardia is essential to maximize the effect of catheter ablation (CA) and to minimize the myocardial injury of CA. An 81-year-old woman presented recurrent palpitations after CA of atrial fibrillation (AF) and atrial tachycardia (AT). She had moderate aortic valve stenosis and coronary artery disease. She had received a pulmonary vein isolation, left atrial (LA) posterior wall isolation, and LA anterior linear ablation for atrial fibrillation 1 year prior. At the start of the procedure, she was in sinus rhythm. Atrial burst pacing induced an AT (230msec). High-density mapping revealed a figure-of-eight activation pattern within the LA appendage (LAA), accounting for 99% of the tachycardia cycle length. The critical isthmus was identified at the mid LAA and the local electrogram of the critical isthmus was not fractionated. A single radiofrequency application at the critical isthmus of the AT, terminated the AT. She was free from any ATs for 28 months. Radiofrequency ablation of the localized reentrant AT was usually performed targeting long fractionated electrograms. In our case, the local electrogram at the critical isthmus was not fragmented compared with the LAA distal part. Long fractionated electrograms were recorded at a more distal part of the LAA than the common isthmus and we could avoid the potential risk of a perforation. A recent developed 3-dimensional electro-anatomical mapping system can identify the critical isthmus and allow us to select a new therapeutic strategy for a critical isthmus ablation of an AT within the LAA.
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