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Updated: Aug 26, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance

Mehrdad Hashemi1, Sahar Hasani2, Shima Hajimazdarany3

  • 1Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence sciences Research Center, Farhikhtegan Hospital Tehran Medical sciences, Islamic Azad University, Tehran, Iran.

International Journal of Biological Macromolecules
|October 3, 2022
PubMed

Insights

Non-coding RNAs (ncRNAs) regulate the Notch signaling pathway, impacting cancer hallmarks like proliferation and metastasis. Understanding this interaction is key for developing novel cancer therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Cancer remains a leading cause of death globally, necessitating innovative therapeutic strategies.
  • Aberrant gene expression in tumorigenesis highlights the importance of targeting regulatory signaling pathways.
  • The Notch signaling pathway plays a crucial role in cellular functions and cancer progression, including proliferation, apoptosis, invasion, metastasis, epithelial-to-mesenchymal transition (EMT), angiogenesis, and immune evasion.

Purpose of the Study:

  • To review the critical role of non-coding RNAs (ncRNAs) in regulating the Notch signaling pathway.
  • To explore how ncRNAs influence key cancer hallmarks.
  • To discuss the implications of ncRNA-Notch pathway interactions in cancer therapy and resistance.

Main Methods:

  • Literature review focusing on ncRNAs (microRNAs and long non-coding RNAs) and their interaction with the Notch pathway.
  • Analysis of studies investigating the role of ncRNAs in cancer hallmarks.
  • Examination of evidence linking ncRNA-mediated Notch regulation to therapeutic resistance.

Main Results:

  • ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are key regulators of the Notch signaling pathway.
  • Dysregulation of ncRNAs impacts various cancer hallmarks such as proliferation, apoptosis, autophagy, EMT, invasion, and metastasis.
  • ncRNAs influence cellular responses to chemo- and radiotherapy by modulating Notch signaling, contributing to therapeutic resistance.

Conclusions:

  • ncRNAs are significant modulators of the Notch pathway in cancer.
  • Targeting ncRNA-mediated regulation of Notch signaling presents a promising avenue for overcoming therapeutic resistance and improving cancer treatment outcomes.
  • Further research into ncRNA-Notch interactions is essential for developing effective cancer therapies.
Keywords:
CancerCancer therapyNotchlncRNAmiRNA

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