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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
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Bone Markings01:26

Bone Markings

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Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Related Experiment Video

Updated: Aug 26, 2025

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
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Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

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Osteoarthritis Bone Marrow Lesions.

D A Walsh1, N Sofat2, A Guermazi3

  • 1Professor of Rheumatology, Pain Centre Versus Arthritis, NIHR Nottingham Biomedical Research Centre, Academic Rheumatology, Division of Injury, Inflammation and Recovery, School of Medicine, University of Nottingham Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom; Consultant Rheumatologist, Sherwood Forest Hospitals NHS Foundation Trust, Mansfield Road, Sutton in Ashfield, NG17 4JL, United Kingdom.

Osteoarthritis and Cartilage
|October 3, 2022
PubMed
Summary
This summary is machine-generated.

Bone marrow lesions (BMLs) are key targets for osteoarthritis (OA) treatment. Understanding BMLs can lead to new therapies that reduce pain and slow OA progression, improving patient lives.

Keywords:
Bone-marrow-lesionDisease-modifying-osteoarthritis-drugsMagnetic-resonance-imagingPain

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Area of Science:

  • Orthopedics
  • Radiology
  • Rheumatology

Background:

  • Bone marrow lesions (BMLs) are associated with osteoarthritis (OA) pain and structural progression.
  • Current understanding of BML pathogenesis and therapeutic targeting remains incomplete.

Purpose of the Study:

  • To review the imaging and pathological characteristics of OA-BMLs.
  • To discuss BMLs' associations with OA symptoms and progression.
  • To explore potential interventions targeting BMLs for OA treatment.

Main Methods:

  • Literature review of imaging, pathology, and clinical associations of OA-BMLs.
  • Critical appraisal of semiquantitative and quantitative BML assessment methods.
  • Discussion of biomechanical and cellular factors in BML pathogenesis.

Main Results:

  • BMLs are linked to OA pain and structural progression.
  • Various imaging methods exist for BML assessment, with varying utility.
  • Pharmacological and non-pharmacological interventions targeting BMLs show potential.

Conclusions:

  • Targeting BMLs offers a promising avenue for OA treatment.
  • Accurate BML assessment is crucial for identifying at-risk patients and evaluating therapies.
  • Further research is needed to confirm the importance of BMLs and develop effective interventions.