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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
352
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

298
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Microbiome-phage interactions in inflammatory bowel disease.

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Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
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Bacteriophages (phages) influence the gut microbiome and may help treat inflammatory bowel disease (IBD). Future research could lead to phage-based therapies for IBD by targeting specific bacteria.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Virology

Background:

  • Inflammatory bowel disease (IBD) involves gut microbiome dysbiosis and systemic inflammation.
  • Bacteriophages (phages), viruses infecting bacteria, are integral to the gut microbiome.
  • Phages may influence bacterial community structure and contribute to IBD pathogenesis.

Purpose of the Study:

  • To review recent advances in understanding endogenous phage roles in healthy and IBD gut microbiomes.
  • To explore the potential of phage therapy for eradicating IBD-associated pathobionts.
  • To highlight phage utilization for preventing and treating IBD and its complications.

Main Methods:

  • Review of peer-reviewed publications from 2013-2022.
  • Focus on the role of phages in healthy and IBD gut ecosystems.
  • Analysis of phage-bacterial interactions and therapeutic potential.

Main Results:

  • Altered phage populations are observed in IBD gut microbiomes.
  • Phages can specifically target and potentially eradicate pathogenic bacteria (pathobionts).
  • Exogenous phage administration shows promise for IBD management.

Conclusions:

  • Understanding phage-gut interactions is key for precision microbiome editing in IBD.
  • Phage therapy offers a targeted approach to pathobiont eradication.
  • Further research is needed to address challenges in phage delivery, specificity, and resistance for effective IBD treatment.