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Nanozyme-Enabled Treatment of Cardio- and Cerebrovascular Diseases
Yihong Zhang1, Wanling Liu1, Xiaoyu Wang1,2
1College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu, 210023, China.
Abstract:
Cardio- and cerebrovascular diseases are two major vascular-related diseases that lead to death worldwide. Reactive oxygen species (ROS) play a vital role in the occurrence and exacerbation of diseases. Excessive ROS induce cellular context damage and lead to tissue dysfunction. Nanozymes, as emerging enzyme mimics, offer a unique perspective for therapy through multifunctional activities, achieving essential results in the treatment of ROS-related cardio- and cerebrovascular diseases by directly scavenging excess ROS or regulating pathologically related molecules. This review first introduces nanozyme-enabled therapeutic mechanisms at the cellular level. Then, the therapies for several typical cardio- and cerebrovascular diseases with nanozymes are discussed, mainly including cardiovascular diseases, ischemia reperfusion injury, and neurological disorders. Finally, the challenges and outlooks for the application of nanozymes are also presented. This review will provide some instructive perspectives on nanozymes and promote the development of enzyme-mimicking strategies in cardio- and cerebrovascular disease therapy.
Insights
Nanozymes, enzyme mimics, combat cardiovascular and cerebrovascular diseases by scavenging reactive oxygen species (ROS). This review explores nanozyme mechanisms and applications for treating these vascular conditions.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Cardio- and cerebrovascular diseases are leading global causes of death.
- Reactive oxygen species (ROS) significantly contribute to disease development and severity.
- Excessive ROS cause cellular damage and tissue dysfunction.
Purpose of the Study:
- To review nanozyme therapeutic mechanisms for ROS-related diseases.
- To discuss nanozyme applications in cardiovascular diseases, ischemia reperfusion injury, and neurological disorders.
- To present challenges and future directions for nanozyme therapy.
Main Methods:
- Review of nanozyme-enabled therapeutic mechanisms at the cellular level.
- Discussion of nanozyme applications in specific cardio- and cerebrovascular diseases.
- Analysis of current challenges and future prospects in the field.
Main Results:
- Nanozymes offer multifunctional activities for treating ROS-related diseases.
- Nanozymes effectively scavenge excess ROS and regulate pathological molecules.
- Demonstrated potential of nanozymes in cardiovascular diseases, I/R injury, and neurological disorders.
Conclusions:
- Nanozymes show promise as enzyme mimics for treating vascular diseases.
- Further development of nanozyme strategies can advance cardio- and cerebrovascular disease therapy.
- This review provides insights into nanozyme applications and future research avenues.
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