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Finite Element Modeling of Powder Compaction: Mini-Tablets in Comparison with Conventionally Sized Tablets.

Luz Nadiezda Naranjo Gómez1,2, Thomas De Beer2, Ashish Kumar3

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Summary

Mini-tablets show similar stress and density profiles to larger tablets, suggesting fewer defects. Beveled punches may increase the risk of cracks and capping failure in pharmaceutical manufacturing.

Keywords:
density distributionfinite element modelingmini-tabletspowder compactionstress distribution

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Engineering
  • Mechanical Engineering

Background:

  • Mini-tablets offer advantages in pharmaceutical dosing and drug delivery.
  • Limited research exists on mini-tablet mechanical properties and manufacturing challenges.
  • Technical aspects like punch geometry effects on stress and density are under-investigated.

Purpose of the Study:

  • Investigate the influence of powder properties and process parameters on mini-tablet mechanical evolution.
  • Analyze the potential for tablet defects during the tableting process.
  • Utilize mechanistic modeling, specifically the Finite Element Method (FEM), for comprehensive analysis.

Main Methods:

  • Simulated four die sizes: 2 mm, 3 mm, 8 mm, and 11.28 mm.
  • Employed four distinct excipients: Avicel PH-102, Kollidon VA64, Pearlitol 100SD, and Supertab 11SD.
  • Utilized two punch geometries: flat-face and bevel-edge.

Main Results:

  • Model predictions showed comparable density and stress distribution profiles between mini-tablets and conventionally sized tablets for specific excipients.
  • Localized differences in density and stress were observed based on tablet size.

Conclusions:

  • Mini-tablets may present a lower risk of tableting defects compared to conventionally sized tablets.
  • Bevel-edged punch designs could potentially increase the risk of crack formation and capping failure.
  • Further investigation into punch geometry and material properties is crucial for optimizing mini-tablet manufacturing.