Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental dysraphism in the rat.

M T Smith, J P Wissinger, C G Smith

    Journal of Neurosurgery
    |November 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer.

    Annals of oncology : official journal of the European Society for Medical Oncology·2022
    Same author

    Infant Effortful Control Mediates Relations Between Nondirective Parenting and Internalising-Related Child Behaviours in an Autism-Enriched Infant Cohort.

    Journal of autism and developmental disorders·2021
    Same author

    Correction: Gulf of Mexico blue hole harbors high levels of novel microbial lineages.

    The ISME journal·2021
    Same author

    Gulf of Mexico blue hole harbors high levels of novel microbial lineages.

    The ISME journal·2021
    Same author

    Anxious parents show higher physiological synchrony with their infants.

    Psychological medicine·2021
    Same author

    Experimental Realization of a Quantum Dot Energy Harvester.

    Physical review letters·2019
    Same journal

    A novel surgical T staging system for recurrent nasopharyngeal carcinoma: advancing prognostic accuracy and clinical applicability.

    Journal of neurosurgery·2026
    Same journal

    De novo aneurysm formation and untreated aneurysm growth after microsurgical clipping: a 20-year prospective cohort study.

    Journal of neurosurgery·2026
    Same journal

    Immune and clinicopathological features of molecularly defined prolactinoma subtypes.

    Journal of neurosurgery·2026
    Same journal

    A nomogram predicting postoperative recurrence risk in SF1/TPIT nonfunctioning pituitary neuroendocrine tumors: integration of tumor heterogeneity quantification on T2-weighted imaging.

    Journal of neurosurgery·2026
    Same journal

    Resection plus stereotactic radiosurgery versus stereotactic radiosurgery alone and control of brain metastasis-induced seizures.

    Journal of neurosurgery·2026
    Same journal

    Predictors of ventricular shunt survival in neoplastic hydrocephalus: a retrospective cohort study of 239 patients.

    Journal of neurosurgery·2026
    See all related articles

    High vitamin A doses in pregnant rats caused birth defects like exencephaly and spina bifida in embryos. These dysraphic lesions result from neural tissue overgrowth, not hydrocephalus.

    Area of Science:

    • Developmental biology
    • Teratology
    • Toxicology

    Background:

    • Dysraphic lesions, including neural tube defects, are significant congenital abnormalities.
    • The precise mechanisms underlying the origin of these lesions remain incompletely understood.
    • Vitamin A is essential for development but can be teratogenic at high doses.

    Purpose of the Study:

    • To investigate the origin of experimental dysraphic lesions in rat embryos.
    • To elucidate the role of neural tissue hyperplasia and epidermal defects in malformation development.
    • To differentiate between hydrocephalus-driven and overgrowth-driven mechanisms for these lesions.

    Main Methods:

    • Administration of high-dose vitamin A (100,000 units) to pregnant rats on specific gestational days (8-10).

    Related Experiment Videos

  • Examination of resulting embryonic litters for malformations, specifically exencephaly and spina bifida.
  • Histological analysis of embryonic lesions to identify cellular and tissue-level changes.

    • Main Results:

    • High vitamin A dosage induced significant rates of exencephaly and/or spina bifida in rat embryos.
    • Embryonic lesions were characterized by neural tube tissue hyperplasia extending to epidermal defects.
    • No evidence of embryonic hydrocephalus was observed; instead, central canals were poorly developed.

    Conclusions:

    • The findings suggest that experimental dysraphic lesions in this model arise from a process of neural tissue overgrowth (hyperplasia) and epidermal defects.
    • The results challenge the hypothesis that embryonic hydrocephalus is the primary cause of these specific malformations.
    • Further research using this and other models is necessary to refine understanding of dysraphic lesion origins.