Related Experiment Video
Updated: Aug 2, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
Population structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin
Siyuan Ma1, Dmitry Shungin2, Himel Mallick2
1Harvard Chan Microbiome in Public Health Center, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
None:
Microbiome studies of inflammatory bowel diseases (IBD) have achieved a scale for meta-analysis of dysbioses among populations. To enable microbial community meta-analyses generally, we develop MMUPHin for normalization, statistical meta-analysis, and population structure discovery using microbial taxonomic and functional profiles. Applying it to ten IBD cohorts, we identify consistent associations, including novel taxa such as Acinetobacter and Turicibacter, and additional exposure and interaction effects. A single gradient of dysbiosis severity is favored over discrete types to summarize IBD microbiome population structure. These results provide a benchmark for characterization of IBD and a framework for meta-analysis of any microbial communities.
Related Concept Videos
Methods to Assess Microbial Communities
Introduction to the Human Microbiota
Microbiota of the Large Intestine
Functions of the Gut Microbiota
Dysbiosis of the Gut Microbiota
Microbiota Modulation by Antibiotics

