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Pathologic complete response following low-dose radiation for advanced oral cavity cancer in a patient with human

Amy B Leming^1,2, Andrea L Johnston³, Greg A Krempl^4,5

¹College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-Rhino-Laryngologie Et De Chirurgie Cervico-Faciale

|October 3, 2022

Abstract

Background:

Advanced squamous cell carcinoma (SCCa) of the oral cavity is often not amenable to curative-intent therapy due to tumor location, tumor size, or comorbidities.

Case Presentation:

A 51-year-old male patient with human immunodeficiency virus and on highly active antiretroviral therapy (HAART) presented with a cT4aN2c SCCa of the tongue. He received a preoperative single course of Quad-Shot radiation therapy to 14 Gy in 4 fractions followed by surgical resection. Patient had no residual carcinoma on surgical pathology and no evidence of disease on subsequent clinical and radiological exams.

Conclusions:

To our knowledge, this is the first case of pathologic complete response for a patient on HAART following a single cycle of the Quad-Shot regimen for advanced oral cavity SCCa. Protease inhibitors in HAART can induce spontaneous tumor regression via inhibition of proteasome function and activation of apoptosis, and thus act as a cancer therapeutic.

Keywords:

HAART HIV Oral cavity cancer Radiation therapy

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