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High APLN Expression Predicts Poor Prognosis for Glioma Patients
Shuangyu Lv1, Yang An1, Huan Dong1
1Institute of Molecular Medicine, Department of Preventive Medicine, Cell Signal Transduction Laboratory, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, Academy for Advanced Interdisciplinary Studies, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
Elevated apelin (APLN) levels indicate poorer survival in low-grade glioma (LGG) patients. This finding suggests APLN could be a valuable prognostic biomarker for LGG, but not glioblastoma (GBM).
Area of Science:
- Neuro-oncology
- Molecular Biology
- Cancer Research
Background:
- The apelin (APLN) and its receptor APJ (APLNR) system plays roles in tumorigenesis and development.
- The prognostic significance of the APLN/APLNR system in central nervous system (CNS) cancers is largely unknown.
Purpose of the Study:
- To investigate the expression, prognostic value, and interaction network of APLN/APLNR in CNS cancers.
- To determine if APLN/APLNR can serve as prognostic biomarkers for low-grade glioma (LGG) and glioblastoma (GBM).
Main Methods:
- Integrated analysis of data from Oncomine, GEPIA, LOGpc, STRING, and GeneMANIA.
- Immunohistochemical staining of APLN expression in LGG tissues.
- Correlation analysis between APLN/APLNR expression and patient survival outcomes (OS, RFS, PFS, DFI, DSS, PFI).
Main Results:
- APLN and APLNR mRNA expression were significantly elevated in CNS cancers (LGG and GBM) compared to normal tissues.
- High APLN expression correlated with poorer overall survival (OS), recurrence-free survival (RFS), and progression-free survival (PFS) in LGG patients.
- APLN expression was higher in LGG grade II than grade I tissues; neither APLN nor APLNR showed prognostic value in GBM.
Conclusions:
- Elevated APLN levels are associated with unfavorable prognoses in LGG patients.
- APLN may serve as a promising prognostic biomarker for LGG.
- The prognostic role of APLN/APLNR in GBM requires further investigation.
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