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Related Experiment Video

Updated: Aug 26, 2025

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Efficient angiogenesis-based wound healing through hydrogel dressing with extracellular vesicles release.

Zhengzhe Han1, Lanlan Dong2, Ang Li1

  • 1Department of Orthopedic Surgery, and Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, PR China.

Materials Today. Bio
|October 4, 2022
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Summary

Periosteum-derived extracellular vesicles (P-sEVs) in a novel hydrogel dressing accelerate wound healing by promoting angiogenesis. This P-sEVs@hydrogel enhances endothelial cell function and tissue regeneration for effective wound repair.

Keywords:
A. HydrogelB. StrengthC. Extracellular vesiclesD. Wound healing dressing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Wound healing and angiogenesis are critical clinical challenges.
  • Periosteum-derived extracellular vesicles (P-sEVs) show promise for promoting tissue repair.
  • Hydrogel dressings offer a versatile platform for delivering therapeutic agents.

Purpose of the Study:

  • To design and evaluate a novel hydrogel wound dressing loaded with P-sEVs for accelerated wound healing.
  • To investigate the angiogenic potential and wound healing efficacy of the P-sEVs@hydrogel.
  • To assess the multifunctional properties of the hydrogel dressing.

Main Methods:

  • Fabrication of a NAGA/GelMA/Laponite/glycerol hydrogel incorporating P-sEVs (P-sEVs@hydrogel).
  • In vitro assessment of P-sEVs' effect on endothelial cell proliferation, migration, and tube formation.
  • In vivo evaluation of P-sEVs@hydrogel in a full-thickness defect wound model.

Main Results:

  • P-sEVs significantly enhanced endothelial cell proliferation, migration, and in vitro tube formation.
  • The P-sEVs@hydrogel dressing demonstrated efficient angiogenesis, tissue adhesion, and barrier function.
  • In vivo studies showed accelerated healing of full-thickness wounds, attributed to stimulated angiogenesis and improved tissue regeneration.

Conclusions:

  • The developed P-sEVs@hydrogel dressing is a multifunctional platform that promotes angiogenesis and accelerates wound healing.
  • Combining bioactive molecules like P-sEVs with advanced hydrogel materials offers a promising strategy for treating full-thickness wound defects.
  • This approach facilitates enhanced cell proliferation, tissue formation, remodeling, and re-epithelialization for satisfactory wound repair.