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Long-Term Changes in HbA1c According to Blood Glucose Control Status During the First 3 Months After Visiting a

Hyunah Kim1, Da Young Jung2, Seung-Hwan Lee3

  • 1College of Pharmacy, Sookmyung Women's University, Seoul, Korea.

Journal of Korean Medical Science
|October 4, 2022
PubMed

Insights

Early blood glucose control in diabetes patients predicts long-term glycemic status. Initial poor control necessitates proactive management to prevent complications and improve outcomes over seven years.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Nephrology

Background:

  • Assessing long-term glycemic control persistence in diabetic patients.
  • Evaluating the impact of initial blood glucose changes on 7-year outcomes.

Purpose of the Study:

  • To determine if early glycemic control predicts long-term blood glucose status.
  • To analyze the association between initial HbA1c changes and subsequent cardiovascular events.

Main Methods:

  • Categorized 9,776 patients into four groups based on HbA1c change within 3 months.
  • Monitored glycemic control, estimated glomerular filtration rate (eGFR), and incidence of stroke and acute coronary syndrome for 7 years.

Main Results:

  • Patients with significant early HbA1c decrease (Best_group) maintained lower levels long-term (P < 0.001).
  • The rate of achieving glycemic targets (<6.5% or <7.0% HbA1c) declined over time.
  • The incidence of decreased eGFR (<30 or <60 mL/min/1.73m²) increased over the study period (P < 0.01).

Conclusions:

  • Early glycemic control within 3 months is a strong predictor of 7-year glycemic control.
  • Poor initial blood glucose control warrants intensified or novel management strategies.
  • This highlights the importance of early intervention for long-term diabetes management and complication prevention.
Abstract

Keywords:
Blood GlucoseDiabetes MellitusGlycemic Control

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