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Multilayer Scaling of a Biomimetic Microfluidic Oxygenator.
Else M Vedula1, Brett C Isenberg1, Jose Santos1
1From the Draper, Cambridge, Massachusetts.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 4, 2022
Summary
A novel microfluidic oxygenator enhances extracorporeal membrane oxygenation (ECMO) by mimicking physiologic blood flow. This advanced device achieves high oxygen transfer rates and blood flow, overcoming ECMO circuit complexities.
Area of Science:
- Biomedical Engineering
- Cardiovascular Technology
- Respiratory Support
Background:
- Extracorporeal membrane oxygenation (ECMO) is advancing due to increased lung disease prevalence and improved technology.
- ECMO circuit complexity, clotting, and bleeding hinder wider adoption.
- Microfluidic advancements offer precise control over critical dimensions and fluid shear.
Purpose of the Study:
- To develop a physiologically inspired multilayer microfluidic oxygenator.
- To improve blood flow patterns and gas transfer efficiency in ECMO devices.
- To address limitations of current ECMO technology through microfluidic innovation.
Main Methods:
- Designed a multilayer microfluidic oxygenator with a 3D distribution manifold.
- Mimicked physiologic blood flow patterns within and between device layers.
- Fabricated microchannels with precise control over dimensions and fluid shear.
Main Results:
- Demonstrated blood flow up to 200 ml/min in a multilayer device.
- Achieved oxygen transfer rates capable of saturating venous blood.
- Reported a maximum blood flow rate of 480 ml/min in an eight-layer device, a microfluidic record.
Conclusions:
- The developed microfluidic oxygenator shows promise for advanced ECMO applications.
- The device design optimizes flow dynamics and gas exchange efficiency.
- Future hemocompatibility and large animal studies are planned to validate performance.
