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Updated: Aug 26, 2025
07:13
The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
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Advances in stress and depression research
Joelle LeMoult1, Ashley M Battaglini, Bronwen Grocott
1Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.
Current Opinion in Psychiatry
|October 4, 2022
Summary
Stress impacts depression, but not everyone exposed to stress develops depression. Recent research explores nuanced biopsychosocial factors, including emotion regulation and biological systems, that influence this link.
Area of Science:
- Psychiatry and Behavioral Sciences
- Neuroscience
- Genetics
Background:
- Stress is a significant factor in depression onset and progression.
- Individual differences in stress response mean only some exposed individuals develop depression.
- Understanding the "when, why, and for whom" of the stress-depression link is crucial for targeted interventions.
Approach:
- Review of recent (18-month) literature on stress and depression.
- Focus on nuanced biopsychosocial mechanisms and moderators.
- Emphasis on diverse methodologies and open science principles.
Key Points:
- Emotion regulation flexibility and interpersonal emotion regulation are key mediators.
- Social support's impact is context-dependent, with varied outcomes.
- Dysregulation in immune, microbiome, endocrine, and neuroanatomical systems exacerbates the stress-depression link.
Conclusions:
- A sophisticated understanding of mechanisms and moderators is essential.
- Future research should prioritize collaborative, open science approaches.
- Investigating the full spectrum of human diversity is critical for generalizability.
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