Sleep quality in Behçet's disease: a systematic literature review

Area of Science:

• Rheumatology
• Sleep Medicine
• Quality of Life Research

Background:

• Behçet's Disease (BD) is linked to impaired sleep and fatigue, negatively affecting quality of life (QoL).
• A comprehensive evaluation of sleep disturbances in BD patients is lacking.
• Existing research suggests a correlation between BD and sleep issues, but a systematic overview is needed.

Approach:

• A systematic literature review (SLR) was conducted to analyze existing evidence on sleep quality in BD patients.
• Fifteen relevant papers were included, focusing on global sleep characteristics and specific sleep disorders in BD.
• Data were analyzed to compare sleep quality metrics and identify associations with disease activity and manifestations.

Key Points:

• Behçet's Disease patients exhibit significantly higher Pittsburgh Sleep Quality Index (PSQI) scores compared to controls.
• Poor sleep quality positively correlates with active disease in 75% of studies examining this relationship.
• Increased PSQI scores are associated with more severe arthritis and genital ulcers in BD patients.

Conclusions:

• Behçet's Disease patients demonstrate lower sleep quality, characterized by altered sleep parameters and a higher incidence of sleep disorders.
• Sleep disturbances in BD are linked to disease activity and specific manifestations like arthritis and genital ulcers.
• Clinical evaluations for BD should incorporate sleep assessments using disease-specific, accessible tools.