Modeling, Simulation and Validation of Alteration in Blood Flow and Regional Oxygenation Under Arterial Occlusion
Dalchand Ahirwar1, Dheeraj Khurana2, Shubhajit Roy Chowdhury3
1Biomedical Systems Laboratory, School of Computing and Electrical Engineering, Indian Institute of Technology, Mandi, India.
Abstract:
The paper presents the mathematical modeling along with an experimental approach for the identification of arterial occlusion condition. Arterial occlusion occurs due to development of constriction and/or thrombus in the lumen of the artery. A geometry of the thrombus has been modeled for the analysis of the arterial occlusion condition in modeling part. The proposed model of the thrombus has been simulated using Comsol® multiphysics considering different hemodynamic parameters. Variation in regional oxygen saturation (rSO2) of the arterial occlusion condition has been validated with experimental process, where occlusion of the artery has been done by applying external pressure. The experimental study has been conducted to monitor alteration in rSO2 level profile for occlusion using near infrared spectroscopy (NIRS) methodology. NIRS signal data has been collected from twenty-three subjects with no reported musculoskeletal, psychiatric, or any other neurological deficits using Mespere NeurOs® oxymeter. Experimental data reveal that the oxygenation level decreases considerably due to arterial occlusion as compared to the healthy condition at 95% of confidence interval (p < .05). Dynamic time warping algorithm reveals that variation in rSO2 due to proposed thrombus geometry has more similarity with experimental study.
More Related Videos
10:40Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
08:35Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
Published on: August 17, 2022
Related Concept Videos
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Blood Flow
