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Outcomes and Risk Factors for Complications in Cataract Patients with Hepatitis C Virus Infection

Karen L Christopher1, Jennifer L Patnaik1, Kylie J Penland1

  • 1Department of Ophthalmology, University of Colorado School of Medicine, Aurora, United States.

Ophthalmic Epidemiology
|October 5, 2022
PubMed

Insights

Hepatitis C virus (HCV) patients undergoing cataract surgery face higher complication risks but achieve excellent visual outcomes. Elevated liver enzymes in HCV patients indicate increased surgical risk.

Area of Science:

  • Ophthalmology
  • Hepatology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection affects liver function and can have systemic implications.
  • Cataract surgery is a common procedure, and understanding patient-specific risks is crucial for optimal outcomes.
  • Assessing outcomes in HCV-positive patients undergoing cataract surgery is important for patient management and surgical planning.

Purpose of the Study:

  • To evaluate the outcomes of cataract surgery in patients with hepatitis C virus (HCV) seropositivity.
  • To identify risk factors associated with surgical complications in HCV-positive individuals undergoing cataract surgery.

Main Methods:

  • Retrospective cohort study including 11,276 eyes from 6,858 patients (2014-2019).
  • Compared outcomes between HCV-positive (1.78%) and HCV-negative patients.
  • Analyzed surgical complications, visual acuity, and postoperative outcomes, including the impact of elevated alanine transaminase.

Main Results:

  • HCV-positive patients had a higher rate of intraoperative complications (2.9% vs 1.2%, OR 2.27).
  • Postoperative best-corrected visual acuity was excellent and comparable between HCV-positive and negative groups.
  • Elevated alanine transaminase in HCV-positive patients was linked to increased intraoperative complication rates (10.0% vs 1.8%, OR 5.53).

Conclusions:

  • HCV-positive patients experience more complications during cataract surgery but achieve excellent visual results.
  • HCV patients tend to undergo cataract surgery at a younger age.
  • Elevated alanine transaminase levels are a significant risk factor for complications in HCV-positive patients undergoing cataract surgery.
Abstract

Keywords:
Hepatitis C viruscataract complicationscataract surgery

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