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Updated: Aug 26, 2025

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

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LEUKOCYTE-EPITHELIAL INTERACTIONS: A DOUBLE-EDGED SWORD THAT PROTECTS AND INJURES DURING HEALTH AND DISEASE

Charles A Parkos1

  • 1ANN ARBOR, MICHIGAN.

Transactions of the American Clinical and Climatological Association
|October 5, 2022
PubMed

Insights

Polymorphonuclear neutrophils (PMNs) are vital for immunity but their dysregulated migration causes gut inflammation. New research explores how PMNs cross the intestinal barrier to inform targeted therapies for conditions like ulcerative colitis.

Area of Science:

  • Immunology
  • Gastroenterology
  • Cell Biology

Background:

  • Polymorphonuclear neutrophils (PMNs) are crucial for innate immunity.
  • Dysregulated PMN infiltration into tissues is linked to various pathologies.
  • Intestinal PMN accumulation correlates with symptoms in conditions like ulcerative colitis.

Purpose of the Study:

  • To highlight molecular insights into PMN transepithelial migration (TEpM).
  • To provide a rationale for developing targeted strategies against pathologic PMN trafficking in the gut.

Main Methods:

  • Utilized in vitro models of PMN TEpM across intestinal epithelial cell lines.
  • Employed innovative animal models to investigate in vivo mechanisms of PMN TEpM.

Main Results:

  • Significant progress has been made in understanding the molecular basis of TEpM.
  • Animal models offer new avenues for studying in vivo regulation of PMN TEpM.

Conclusions:

  • Understanding PMN TEpM is key to addressing gut inflammation.
  • Targeted strategies can mitigate the pathologic consequences of dysregulated PMN trafficking in the gut.

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