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Increasing Pre-pregnancy Body Mass Index and Pregnancy Outcomes in the United States
Oluwasegun A Akinyemi1,2, Resham Tanna3, Stella Adetokunbo4
1Department of Health Policy and Management, University of Maryland School of Public Health, College Park, USA.
Insights
Increasing pre-pregnancy body mass index (BMI) is linked to adverse maternal and neonatal outcomes. This risk persists even after accounting for other factors, highlighting the importance of pre-pregnancy weight management.
Area of Science:
- Obstetrics and Gynecology
- Public Health
- Perinatal Medicine
Background:
- Rising rates of overweight and obesity in American women.
- Normalization of increased body mass index (BMI).
- Need for research on pre-pregnancy obesity and pregnancy outcomes.
Purpose of the Study:
- To determine the association between increasing pre-pregnancy BMI and adverse pregnancy outcomes.
Main Methods:
- Utilized US Vital Statistics records (2015-2019) for 15,627,572 deliveries.
- Employed multivariate analysis to assess the association between pre-pregnancy BMI and maternal/neonatal outcomes.
- Controlled for numerous maternal, paternal, and pregnancy-related covariates.
Main Results:
- Pre-pregnancy BMI distribution: 3.36% underweight, 43.19% normal, 26.34% overweight, 14.73% obese class I, 7.23% obese class II, 5.14% obese class III.
- Increasing pre-pregnancy BMI showed significant associations with adverse maternal and neonatal outcomes.
- Adverse outcome risks persisted across all BMI categories compared to normal BMI.
Conclusions:
- A strong association exists between elevated pre-pregnancy BMI and adverse maternal and neonatal outcomes.
- The increased risk of adverse pregnancy outcomes in overweight and obese women is independent of traditional risk factors.
- Highlights the critical impact of pre-pregnancy weight on pregnancy health.
Introduction:
As many Americans are becoming overweight or obese, increased body mass index (BMI) is fast becoming normalized. There is a need for more research that highlights the association between pre-pregnancy obesity and adverse pregnancy outcomes.
Aim:
To determine the association between increasing pre-pregnancy BMI and adverse pregnancy outcomes.
Methods:
We utilized the United States Vital Statistics records to collate data on all childbirths in the United States between 2015 and 2019. We determined the association between increasing pre-pregnancy BMI and adverse pregnancy outcomes using multivariate analysis. Neonatal outcomes measures include the five-minute Apgar score, neonatal unit admission, neonates receiving assisted ventilation > six hours, neonatal antibiotics use, and neonatal seizures. Maternal outcomes include cesarean section rate, mothers requiring blood transfusion, unplanned hysterectomy, and intensive care unit admission. In addition, we controlled for maternal parameters such as race/ethnicity, age, insurance type, and pre-existing conditions such as chronic hypertension and prediabetes. Other covariates include paternal race, age and education level, gestational diabetes mellitus, induction of labor, weight gain during pregnancy, gestational age at delivery, and delivery weight.
Results:
We studied 15,627,572 deliveries in the US Vital Statistics records between 2015 and 2019. Among these women, 3.36% were underweight, 43.19% were with a normal BMI, 26.34% were overweight, 14.73% were in the obese class I, 7.23% were in the obese class II, and 5.14% were in the obese class III. Increasing pre-pregnancy BMI was associated with significant adverse outcomes across all measures of maternal and neonatal outcomes.
Conclusion:
A strong association exists between increasing pre-pregnancy BMI and adverse maternal and neonatal outcomes. The higher risk of adverse pregnancy outcomes among overweight and obese women remained even after controlling for other traditional risk factors of adverse maternal and neonatal outcomes.
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