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Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington's disease

Sudeepto Saha1, Manami Jayati Dey2, Salman Khan Promon1

  • 1Department of Life Sciences, School of Environment and Life Sciences, Independent University, Bangladesh (IUB), Dhaka, Bangladesh.

Regenerative Therapy
|October 5, 2022
PubMed

Insights

Huntington's disease (HD) is a fatal neurodegenerative disorder. Stem cell therapy shows promise as a potential cure by addressing the underlying cause, offering hope beyond symptom management.

Area of Science:

  • Neuroscience
  • Genetics
  • Regenerative Medicine

Background:

  • Huntington's disease (HD) is a progressive, fatal neurodegenerative disorder.
  • Caused by CAG/glutamine repeats in the Huntington gene, leading to movement, cognitive, and affective impairments.
  • Current treatments only manage symptoms, not the disease's root cause.

Purpose of the Study:

  • To review the pathogenesis of Huntington's disease.
  • To evaluate the efficacy and clinical practicality of stem cell transplantation for HD.
  • To analyze the application of stem cell therapy in genetically altered HD animal models.

Main Methods:

  • Literature review focusing on Huntington's disease pathogenesis.
  • Analysis of studies on stem cell transplantation in HD.
  • Examination of data from genetically modified animal models of HD.

Main Results:

  • Stem cell therapy presents a potential breakthrough for treating Huntington's disease.
  • Research in animal models is crucial for understanding HD pathogenesis and therapeutic potential.
  • The review analyzes the application and effectiveness of stem cell transplantation in preclinical HD models.

Conclusions:

  • Stem cell transplantation offers a promising therapeutic avenue for Huntington's disease.
  • Further research and clinical application in animal models are essential.
  • This approach could lead to a cure by targeting the disease's underlying genetic cause.

Keywords:
Huntington's diseasePathogenesisStem cells transplantationTherapeutics

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