Related Experiment Video
Updated: Aug 26, 2025
Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
Published on: June 27, 2025
Endometrial regeneration in Asherman's syndrome and endometrial atrophy using Wharton's jelly-derived mesenchymal
Jaroslaw B Kaczynski1,2, Jakub K Rzepka3,4
1De Cure Medical Research, Warsaw, Poland. jarekkaczynski71@gmail.com.
Objectives:
Reconstruction of the endometrium in patients with endometrial atrophy and Asherman's syndrome using Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs).
Material And Methods:
Prospective pilot study, with the inclusion of two patients.
Results:
After administration of WJ-MSCs into the uterine cavity, endometrial reconstruction was achieved in both patients. Pregnancy was achieved in one of them, after transfer of a frozen embryo, completed by delivery around the due date.
Conclusions:
Endometrial atrophy and Asherman's syndrome, is one of the most frustrating clinical situations we face in assisted reproductive procedures. The use of Wharton's jelly-derived mesenchymal stem cells in restoring the normal function of the endometrium, could become an easy and accessible therapeutic medal, for this endometrial dysfunction, which is so difficult to treat.
More Related Videos
04:47Author Spotlight: Advancements in Stem Cell-Derived Vascularized Organoids and Optimized Isolation of Wharton's Jelly for Enhanced MSC Production
Published on: July 5, 2024
09:15Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
