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Updated: Aug 26, 2025
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Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
Published on: October 15, 2018
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Dangerous Liaisons between Tet2 Mutation, Inflammatory Monocytes, and Leukemogenesis
Eric M Pietras1, James DeGregori1,2
1Department of Medicine, Section of Hematology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Cancer Discovery
|October 5, 2022
Abstract:
Transgenic knockin mice expressing a common loss-of-function mutation in human TET2 exhibit aging-related accelerated myeloid leukemia development and skewing of myelopoiesis toward the production of proinflammatory MHC-IIhi monocytes that may contribute to disease. See related article by Yeaton et al., p. 2392 (2).
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