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Tools for manipulation and positioning of microtissues.

Emilie Vuille-Dit-Bille1,2, Dhananjay V Deshmukh3,4, Sinéad Connolly5

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Summary

Precise manipulation of microtissues is crucial for advancing personalized medicine research. This review categorizes and analyzes tools for microtissue positioning, essential for drug development and regenerative medicine applications.

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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Drug Development

Background:

  • Three-dimensional (3D) in vitro models are vital for personalized medicine.
  • Microtissue manipulation and positioning are critical for the microtissue lifecycle.
  • Standardization of microtissue manipulation techniques is essential for reliable research.

Purpose of the Study:

  • To comprehensively review existing tools for microtissue manipulation and positioning.
  • To classify and analyze different microtissue positioning techniques.
  • To evaluate the potential of these tools for advancing personalized medicine.

Main Methods:

  • Categorization of microtissue positioning techniques into four main groups: hydrodynamic, bioprinting, substrate modification, and non-contact active forces.
  • Review of reported tools for microtissue manipulation and positioning.
  • Analysis of the working mechanisms, merits, and limitations of each technique.

Main Results:

  • Microtissue positioning techniques are diverse, including hydrodynamic, bioprinting, substrate modification, and non-contact active forces.
  • Each technique presents unique advantages and disadvantages impacting efficiency and control.
  • The field of microtissue manipulation is rapidly evolving.

Conclusions:

  • Standardized microtissue manipulation tools are key to improving the efficiency and reliability of personalized medicine research.
  • Further development and evaluation of these tools are needed to fully realize their potential in drug development and regenerative medicine.
  • Advancements in microtissue positioning will accelerate progress in personalized medicine.