Significance of MCP-1 in predicting the short-term recurrence of primary intussusception in children: An...

Area of Science:

• Pediatric Gastroenterology
• Immunology
• Biomarker Research

Background:

• Intussusception is a common pediatric surgical emergency.
• Short-term recurrence of intussusception can occur after initial treatment.
• Identifying reliable predictors of recurrence is crucial for patient management.

Purpose of the Study:

• To investigate the association between peripheral blood monocyte chemoattractant protein-1 (MCP-1) levels and short-term recurrence of primary intussusception in children.
• To evaluate MCP-1 as a potential biomarker for predicting intussusception recurrence.

Main Methods:

• Retrospective analysis of 412 children with primary intussusception treated with ultrasound-guided hydrostatic reduction.
• Measurement of MCP-1 levels in peripheral venous blood using Enzyme-linked immunosorbent assay.
• Logistic regression and Receiver Operating Curve (ROC) analysis to assess risk factors and diagnostic efficacy.

Main Results:

• Children with short-term intussusception recurrence exhibited significantly higher MCP-1 levels (P < .05).
• Elevated MCP-1 was identified as a significant risk factor for recurrence.
• ROC analysis indicated a cut-off value of 23.24 ng/mL for MCP-1, with 82.14% sensitivity and 75.67% specificity for predicting recurrence.

Conclusions:

• Increased peripheral blood MCP-1 expression is observed in children with short-term recurrence of primary intussusception.
• Elevated MCP-1 serves as a valuable risk factor for predicting short-term intussusception recurrence in children.
• MCP-1 demonstrates potential clinical utility as a biomarker for anticipating intussusception recurrence.