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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Synthetic biodegradable polyesters for implantable controlled-release devices.

Jinal U Pothupitiya1,2,3,4, Christy Zheng1,2,3,4, W Mark Saltzman1,2,3,4

  • 1Department of Biomedical Engineering, Yale University, New Haven, CT, USA.

Expert Opinion on Drug Delivery
|October 5, 2022
PubMed
Summary
This summary is machine-generated.

Biodegradable polyester implants offer controlled drug release for various medical applications. These advanced drug delivery systems provide sustained therapeutic effects with high bioavailability and low toxicity.

Keywords:
Polyesterbiodegradable implantscontrolled releasepolymeric implants

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Area of Science:

  • Biomaterials Science
  • Polymer Engineering
  • Drug Delivery Systems

Background:

  • Implantable devices enable sustained drug release to localized tissues.
  • Advances in polymer engineering facilitate predictable drug release profiles.
  • Biodegradable polyesters possess suitable properties for medical implants.

Approach:

  • Review of commonly used biodegradable polyesters.
  • Discussion of implant formulation and manufacturing techniques.
  • Analysis of drug release mechanisms and clinical applications.

Key Points:

  • Polyester-based implants are crucial for controlled drug release technologies.
  • These implants offer high bioavailability and low toxicity.
  • They are widely used in pain management, cancer therapy, and antiviral treatments.

Conclusions:

  • Biodegradable polyesters are versatile materials for drug-loaded implants.
  • Polyester implants represent a significant class of drug delivery devices.
  • Many polyester-based implants have reached human testing or clinical approval.