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Related Experiment Video

Updated: Aug 26, 2025

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

CMU Array: A 3D nanoprinted, fully customizable high-density microelectrode array platform.

Mohammad Sadeq Saleh¹, Sandra M Ritchie¹, Mark A Nicholas^2,3

¹Department of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Science Advances

|October 5, 2022

Summary

This summary is machine-generated.

Researchers developed customizable 3D printed microelectrode arrays for brain research. These flexible, robust devices offer high channel density and excellent signal quality for precise electrophysiological recordings in vivo.

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Last Updated: Aug 26, 2025

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Area of Science:

Neuroscience
Biomedical Engineering
Materials Science

Background:

Microelectrode arrays are essential for recording brain activity.
Current electrode technology lacks customization, limiting experimental applications.
Existing electrodes face challenges in coverage, durability, and cost.

Purpose of the Study:

To introduce a novel 3D nanoparticle printing method for creating customizable microelectrode arrays.
To overcome the limitations of conventional electrodes in terms of flexibility, coverage, and robustness.
To demonstrate the feasibility of in vivo electrophysiological recordings using these 3D printed devices.

Main Methods:

Utilized a 3D nanoparticle printing approach for fabricating multi-electrode devices.
Designed customizable electrode layouts with flexible shank lengths and configurations.
Integrated custom 3D printed multilayer circuit boards for enhanced functionality.

Main Results:

Achieved high electrode densities (2600 channels/cm²).
Demonstrated in vivo recordings with excellent signal-to-noise ratio and low channel impedances.
Confirmed minimal gross tissue damage due to the flexible and robust nature of the devices.

Conclusions:

3D printed microelectrode arrays offer a customizable and robust solution for brain research.
This fabrication method enables targeted and large-scale electrophysiological recordings.
The technology presents significant advancements for biomedical device development.