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Updated: Aug 26, 2025

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute

Jun Shirakawa1, Yu Togashi2, Giorgio Basile3

  • 1Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA; Laboratory of Diabetes and Metabolic Disorders, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 3718512, Japan; Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama-City University, Yokohama 2360004, Japan.

Cell Reports
|October 5, 2022
PubMed

Keywords:
CP: MetabolismE2F1acute insulin resistanceadipocytescompensationhuman beta cellsinsulin receptorinter-organ communicationtranscription factorβ cell proliferation

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