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Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
Published on: December 18, 2010
Cap CASP, not SCAP, to fight steatohepatitis
1Gastroenterology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Genetics Division, Brigham and Women's Hospital, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
Abstract:
Hepatic lipid synthesis through SREBP has recently been found to be regulated not only through the canonical pathway involving SCAP in response to sterol deficiency, but also through the PIDDosome and CASP2. In this issue, Kim et al. identify a novel interaction between these two pathways in diet-induced non-alcoholic steatohepatitis.
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