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Updated: Aug 26, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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[GVHD: pathophysiology and novel agents]

Takahide Ara1, Daigo Hashimoto1

  • 1Department of Hematology, Hokkaido University Faculty of Medicine.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 5, 2022
PubMed

Graft-versus-host disease (GVHD) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-SCT). Recent advances in understanding the GVHD pathophysiology promoted development of novel therapeutic agents for GVHD. In acute GVHD, emerging evidence suggested that it targets tissue stem cells in the skin, liver, and gut, resulting in treatment refractoriness. Furthermore, antimicrobial peptide deficiency, nutritional status alteration of the gut microbiota, and antibiotic administration lead to gut dysbiosis, which is related to GVHD onset and treatment-related mortality after allo-SCT. In this review, recent advances in understanding the GVHD pathophysiology are summarized, and novel agents for the treatment and prophylaxis of acute and chronic GVHD are introduced.

Keywords:
Allogeneic stem cell transplantationGVHDGraft-versus-host disease

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